|PUBLICATIONS (Ranked by impact factor of the journal)|
In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity|
Researchers used two-photon microscopy to quantify cytotoxic T lymphocyte (CTL)-mediated killing in mice infected with herpesviruses or poxviruses. During killing, CTLs remained migratory and formed motile kinapses rather than static synapses with targets. [Immunity] Abstract
Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection
Scientists applied genomic mapping strategies and multicolor flow cytometric analysis of immune cells in naive and virus-infected hosts to identify genetic modifiers of the host immune response to murine cytomegalovirus. [PLoS Pathog] Full Article
IL-4-Producing ILC2s Are Required for the Differentiation of TH2 Cells following Heligmosomoides polygyrus Infection
Using H. polygyrus, which is controlled by IL-4-dependent immunity, researchers identified that group-2 innate lymphoid cells (ILC2s) produced significant amounts of IL-4 and IL-2 following H. polygyrus infection. [Mucosal Immunol] Full Article
IGHV1-69 Polymorphism Modulates Anti-Influenza Antibody Repertoires, Correlates with IGHV Utilization Shifts and Varies by Ethnicity
Researchers studied a cohort of NIH H5N1 vaccinees and demonstrate for the first time the influence of IGHV1‑69 polymorphism on V-segment usage, somatic hypermutation and B cell expansion that elucidates the dominance of F-alleles in HV1-69-sBnAbs. [Sci Rep] Full Article
Cryptococcus neoformans Thermotolerance to Avian Body Temperature Is Sufficient for Extracellular Growth but Not Intracellular Survival In Macrophages
Scientists found that bird macrophages are able to suppress the growth of cryptococci seen in mammalian cells despite C. neoformans being able to grow at bird body temperature, and are able to escape from bird macrophages by vomocytosis. [Sci Rep] Full Article
Fc Receptor-Mediated Phagocytosis in Tissues as a Potent Mechanism for Preventive and Therapeutic HIV Vaccine Strategies
Scientists aimed to define the landscape of effector cells and Fc receptors present within vulnerable tissues. They found negligible Fc receptor-expressing natural killer cells in the female reproductive and gastrointestinal mucosa. [Mucosal Immunol] Abstract
CCR6− Regulatory T Cells Blunt the Restoration of Gut Th17 Cells along the CCR6–CCL20 Axis in Treated HIV-1-Infected Individuals
Investigators showed that the CCR6–CCL20 chemotactic axis is altered, with reduced CCL20 production by small intestine epithelial cells in treated HIV-1-infected individuals. This leads to impaired CCR6+CD4+ T-cell homing, particularly T helper type 17 (Th17) cells, to the small intestine mucosa. [Mucosal Immunol] Abstract
Streamlining Heterologous DNA-Prime and NYVAC/Protein-Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens
Investigators assessed in non-human primates whether such vaccination regimens can be further streamlined using fewer and accelerated immunizations when employing a novel generation of improved DNA-C and NYVAC-C vaccine candidates designed for higher expression levels and more balanced immune responses. [J Virol] Abstract
Subscribe to our sister publications: Human Immunology News and Immune Regulation News!
HIV-1 Reservoirs During Suppressive Therapy|
Over the past few years, significant progress has been made in defining and characterizing the latent reservoir of HIV-1, and the authors review how understanding the latent reservoir during suppressive therapy will lead to significant advances in curative approaches for HIV-1. [Trends Microbiol] Abstract
Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.
NEW ECCMID 2016 |
April 9-12, 2016
Visit our events page to see a complete list of events in the immunology of infectious disease community.