Single Dose Ebola Vaccine Is Safe and Effective in Monkeys against Outbreak Strain
Scientists report that a single dose of an experimental Ebola virus (EBOV) vaccine completely protects cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona, when given at least seven days before exposure, and partially protects them if given three days prior. [Press release from the National Institutes of Health discussing online prepublication in Science] Press Release|Full Article
Exposure to SIV In Utero Results in Reduced Viral Loads and Altered Responsiveness to Postnatal Challenge
Researchers hypothesized that fetal exposure to HIV may render the fetus tolerant to the virus, thus reducing damage caused by immune activation during infection later in life. To test this hypothesis, fetal rhesus macaques were injected with the attenuated virus SIVmac1A11 in utero and challenged with pathogenic SIVmac239 one year after birth. [Sci Transl Med] Abstract
Syncytial Apoptosis Signaling Network Induced by the HIV-1 Envelope Glycoprotein Complex: An Overview
Investigators present a detailed and curated map of the syncytial apoptosis signaling network, aimed at simplifying the whole mechanism that they have characterized at the molecular level in the last 15 years. The simplification of this complex network paves the way for the development of novel therapeutic strategies to eradicate HIV-1 infection. [Cell Death Dis] Full Article
The Role of Th17 and Treg Responses in the Pathogenesis of RSV Infection
Two subsets of the cellular immune response, the T helper 17 cell (Th17) and the regulatory T cell (Treg), and more particularly the balance between these two subsets, might play a significant role in the pathogenesis of the respiratory syncytial virus (RSV) infection. [Pediatr Res] Abstract
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INDUSTRY NEWS
Northwestern Receives $17 Million Grant for HIV Prevention Research
Northwestern Medicine scientists have received a 5-year, $17.5 million grant from the National Institutes of Health for an interdisciplinary project that aims to invent, develop and test an implantable drug delivery system to protect high-risk individuals from HIV infection for up to a year at a time. [Northwestern Medicine] Press Release
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