| | | PUBLICATIONS (Ranked by impact factor of the journal) |
Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow
Investigators used CD19, CD38, and CD138 to identify four plasma cell (PC) subsets in human bone marrow (BM). They found that the CD19−CD38hiCD138+ subset was morphologically distinct, differentially expressed PC-associated genes, and exclusively contained PCs specific for viral antigens to which the subjects had not been exposed for more than 40 years. [Immunity]
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Press Release
Inhibition of Ebola Virus Glycoprotein-Mediated Cytotoxicity by Targeting Its Transmembrane Domain and Cholesterol
Researchers report that the membrane-anchored glycoprotein (GP) is sufficient to induce the detachment of adherent cells. They showed that the detachment induced through either full-length GP1,2 or the subunit GP2 depends on cholesterol and the structure of the transmembrane domain. [Nat Commun]
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Press Release
Dengue Virus Infection Elicits Highly Polarized CX3CR1+ Cytotoxic CD4+ T Cells Associated with Protective Immunity
Researchers defined HLA-restricted CD4+ T-cell epitopes resulting from natural infection with dengue virus in a hyperepidemic setting. Ex vivo flow-cytometric analysis of DENV-specific CD4+ T cells revealed that the virus-specific cells were highly polarized, with a strong bias toward a CX3CR1+ Eomesodermin+ perforin+ granzyme B+ CD45RA+ CD4 CTL phenotype. [Proc Natl Acad Sci USA]
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An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus
Scientists showed that mice were broadly protected against challenge with a wide variety of lethal influenza A virus infections with a virus-like particle vaccine cocktail. [mBio] Full Article
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Press Release
Regulation of T Cell Function by MicroRNA-720
Invesitgators demonstrated that the percentage of hepatitis B virus (HBV)-specific CD8+ T cells is higher in the spleen of chronic HBV infection patients than that from peripheral blood and liver. miR-720 expression is upregulated in HBV-specific CD8+ T cells. [Sci Rep] Full Article
HIV
Antigen-Specific NK Cell Memory in Rhesus Macaques
Scientists found that splenic and hepatic natural killer (NK) cells from SHIVSF162P3-infected and SIVmac251-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. [Nat Immunol] Abstract
Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells
Investigators showed that Vpu, the HIV-1 antagonist of BST2, suppresses TLR7-mediated type-I interferon production by plasmacytoid dendritic cells through a mechanism that relies on the interaction of BST2 on HIV-producing cells with ILT7. [PLoS Pathog] Full Article
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Press Release
Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers
Scientists showed that exposure of conventional dendritic cells from elite controllers to HIV-1 leads to a rapid and sustained production of type I interferons and upregulation of several interferon-stimulated effector genes. [PLoS Pathog] Full Article
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Press Release
Bryostatin Activates HIV-1 Latent Expression in Human Astrocytes through a PKC and NF-ĸB-Dependent Mechanism
To broaden the inhibitory range and effectiveness of current antiretrovirals, the potential of bryostatin was investigated as a latent HIV-1 activator. Bryostatin reactivates latent viral infection in the NHA and U87 cells via activation of protein kinase C (PKC)-alpha and -delta, because the PKC inhibitors rottlerin and GF109203X abrogated the bryostatin effect. [Sci Rep] Full Article
Langerhans Cell–Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1
Investigators demonstrated that langerin not only functions as a pattern recognition receptor but also as an adhesion receptor mediating clustering between Langerhans cells and dendritic cells. [J Immunol] Abstract
Restoration of CD4+ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype
To better understand the dynamics of Ag-specific CD4+ T cells during antiretroviral therapy (ART), scientists assessed the frequency, functional capacity, and memory profile of CD4+ T cells specific for Mycobacterium tuberculosis and CMV in 15 HIV-infected individuals before and 1 y after ART initiation [J Immunol] Abstract
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| | | REVIEWS |
HIV-1 Capsid: The Multifaceted Key Player in HIV-1 Infection
The authors review the curre understanding of the interactions between the viral capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and the integration of the viral genome into the genome of the target cell. [Nat Rev Microbiol] Abstract
Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.
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| | | SCIENCE NEWS |
Cholesterol Metabolism in Immune Cells Linked to HIV Progression
Lower levels of cholesterol in certain immune cells—a result of enhanced cholesterol metabolism within those cells—may help explain why some HIV-infected people are able to naturally control disease progression. [Press release from the National Institutes of Health discussing research presented at the 8th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver]
Press Release
Starting Antiretroviral Treatment Early Improves Outcomes for HIV-Infected Individuals
A major international randomized clinical trial has found that HIV-infected individuals have a considerably lower risk of developing AIDS or other serious illnesses if they start taking antiretroviral drugs sooner, when their CD4+ T-cell count—a key measure of immune system health—is higher, instead of waiting until the CD4+ cell count drops to lower levels. [Press release from the National Institutes of Health discussing research presented at the 8th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver]
Press Release
Argos Therapeutics to Present at 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Argos Therapeutics Inc. announced Irina Tcherepanova, Ph.D. will participate in a roundtable discussion on combination therapy trials at the “Towards an HIV Cure” symposium. [Press release from Argos Therapeutics Inc. discussing research to be presented at the 8th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver]
Press Release
Novavax Announces Positive Top-Line Data from Phase I Ebola Vaccine Trial on WHO Teleconference
Novavax, Inc. announced positive top-line data from a Phase I clinical trial of its Ebola virus glycoprotein recombinant nanoparticle vaccine candidate adjuvanted with Matrix-M™. [Press release from Novavax, Inc. discussing research presented at the World Health Organization’s (WHO) Fifth Teleconference on Ebola Vaccine Clinical Trials] Press Release
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