Research on Gonorrhea Uncovers New Immune System Trigger
Researchers have uncovered how Gram-negative bacteria — a broad class of bugs that cause diseases ranging from gonorrhea to diarrhea and pneumonia — can trigger a reaction from our immune system. [Press release from the University of Toronto discussing online publication in Science] Press Release|Abstract
Structure-Based Redesign of Lysostaphin Yields Potent Antistaphylococcal Enzymes that Evade Immune Cell Surveillance
Investigators deimmunized lysostaphin using a computationally guided process that optimizes sets of mutations to delete immunogenic T cell epitopes without disrupting protein function. In vitro analyses showed the methods to be both efficient and effective, producing seven different deimmunized designs exhibiting high function and reduced immunogenic potential. [Mol Ther Methods Clin Dev] Full Article
HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells
Researchers used a dual reporter virus—HIV Duo-Fluo I, which identifies latently infected cells immediately after infection—to investigate how T cell activation affects the establishment of HIV latency. They showed that HIV latency can arise from the direct infection of both resting and activated CD4+ T cells. [PLoS Pathog] Full Article
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INDUSTRY NEWS
GARDASIL®9: New HPV Vaccine Approved in the European Union
Sanofi Pasteur MSD announced that the European Commission has granted marketing authorization for GARDASIL 9. GARDASIL 9 is a 9-valent HPV vaccine for active immunization of females and males from the age of nine years against premalignant lesions and cancers affecting the cervix, vulva, vagina or anus and also against genital warts caused by the HPV types covered by the vaccine. [Sanofi Pasteur MSD] Press Release
CHOP’s Dr. Steven Douglas Honored as Paradigm Builder in HIV-Immunology Research
Steven D. Douglas, M.D., chief of the Section of Immunology at The Children’s Hospital of Philadelphia, was recognized for 40 years of seminal and continuous work in the biology of immune cells, with particular relevance to potential treatment for HIV infection. [Children’s Hospital of Philadelphia] Press Release
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