Volume 3.12 | Apr 1

Immunology of Infectious Disease News 3.12 April 1, 2015
Immunology of Infectious Disease News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
Like Us on Facebook  IIDN on Twitter
Ebola Whole Virus Vaccine Shown Effective, Safe in Primates
An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus. [Press release from University of Wisconsin-Madison discussing online prepublication in Science] Press Release | Abstract
Enter to Win a Travel Support Award to ISSCR2015!
PUBLICATIONS (Ranked by impact factor of the journal)
Safety and Immunogenicity of a Novel Recombinant Adenovirus Type-5 Vector-Based Ebola Vaccine in Healthy Adults in China: Preliminary Report of a Randomized, Double-Blind, Placebo-Controlled, Phase I Trial
Investigators assessed the safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine expressing the glycoprotein of the 2014 epidemic strain. Their findings show that the high-dose vaccine is safe and robustly immunogenic. [Lancet] Full Article | Press Release

Prostaglandin E2 and Programmed Cell Death 1 Signaling Coordinately Impair CTL Function and Survival during Chronic Viral Infection
Researchers found that the prostaglandin E2 receptors EP2 and EP4 were upregulated on virus-specific cytotoxic T lymphocytes (CTLs) during chronic lymphocytic choriomeningitis virus infection and suppressed CTL survival and function. [Nat Med] Abstract | Press Release

T Cell Lipid Peroxidation Induces Ferroptosis and Prevents Immunity to Infection
Scientists investigated the importance of glutathione peroxidase 4 (Gpx4) for physiological T cell responses by using T cell-specific Gpx4-deficient mice. Their results revealed that, despite normal thymic T cell development, CD8+ T cells from TΔGpx4/ΔGpx4 mice had an intrinsic defect in maintaining homeostatic balance in the periphery. [J Exp Med] Abstract

Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin
Researchers found that the dominant function of autophagy proteins during infections with the epidemic community-associated methicillin-resistant S. aureus USA300 is to mediate tolerance rather than resistance. Atg16L1 hypomorphic mice, which have reduced autophagy, were highly susceptible to lethality in both sepsis and pneumonia models of USA300 infection. [Cell Host Microbe] Abstract | Graphical Abstract

Trained Immunity in Newborn Infants of HBV-Infected Mothers
Scientists demonstrated that Hepatitis B virus (HBV) exposure in utero triggered a state of trained immunity, characterized by innate immune cell maturation and Th1 development, which in turn enhanced the ability of cord blood immune cells to respond to bacterial infection in vitro. [Nat Commun] Full Article | Press Release


Ex Vivo Analysis Identifies Effective HIV-1 Latency-Reversing Drug Combinations
Using resting CD4+ T cells from infected individuals, scientists developed an experimental and theoretical framework to identify effective latency-reversing agent (LRA) combinations. Utilizing ex vivo assays for intracellular HIV-1 mRNA and virion production, they compared two-drug combinations of leading candidate LRAs and identified multiple combinations that effectively reverse latency. [J Clin Invest]
Full Article | Press Release

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection
Investigators examined the frequency of elevated cerebrospinal fluid (CSF) HIV-1 RNA concentration, the nature of CSF viral populations compared to the blood, and the presence of a cellular inflammatory response (with the potential to bring infected cells into the central nervous system) using paired CSF and blood samples obtained over the first two years of infection from 72 ART-naïve subjects. [PLoS Pathog] Full Article | Press Release

Decreased HIV-Specific T-Regulatory Responses Are Associated with Effective DC-Vaccine Induced Immunity
Scientists reported that vaccination with ex vivo-generated dendritic-cells (DC) loaded with HIV-lipopeptides in HIV-infected patients was well tolerated and highly immunogenic. [PLoS Pathog] Full Article

Colorectal Mucus Binds DC-SIGN and Inhibits HIV-1 Trans-Infection of CD4+ T-Lymphocytes
Colorectal mucus from a number of individuals was collected and tested for the capacity to bind DC-SIGN and inhibit HIV-1 cis– or trans-infection of CD4+ T-lymphocytes. [PLoS One] Full Article

Persistence of Pathological Distribution of NK Cells in HIV-Infected Patients with Prolonged Use of HAART and a Sustained Immune Response
Investigators conducted a prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors in HIV patients with long-term HAART use and sustained virological and immunological response. [PLoS One] Full Article

Subscribe to our sister publications: Human Immunology News and Immune Regulation News!

Perform automated cell isolation from up to 16 samples at once with RoboSep™-16.
Mycobacterium tuberculosis Infection of the ‘Non-Classical Immune Cell’
The authors address the influence of specific ‘non-classical immune cells’ in host responses and their effects in controlling mycobacterial growth or enabling an environment conducive for bacilli persistence. [Immunol Cell Biol] Full Article

Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.

Your Favorite Immunology Newsletters Are Now on Facebook! Like Us Today!
Oral Hepatitis B Vaccine Could Become a Reality
Researchers report progress toward perfecting a radical new method of producing vaccines using genetically modified corn. The approach could lead to an oral hepatitis B vaccine that requires no refrigeration and costs less than $1 per dose to manufacture. [Press release from the Federation of American Societies for Experimental Biology (Newswise, Inc.) discussing research presented at Experimental Biology 2015, Boston] Press Release

From our sponsor: Working with blood? Download the immune cell frequencies app.
NIH Funds Study of Fully Personalized Immunotherapy AGS-004 Combined with a Latency Reversing Therapy for the Treatment of HIV
Argos Therapeutics, Inc. announced that the NIH Division of AIDS has approved $6.6 million in funding for an investigator-initiated Phase IIa adult eradication study of AGS-004, the company’s investigational fully personalized immunotherapy for HIV. [Argos Therapeutics, Inc.] Press Release

Immune Response BioPharma, Inc. Announces the FDA has Accepted REMUNE HIV/AIDS Vaccine BLA for Review
Immune Response BioPharma, Inc. provided an update on REMUNE and announced the FDA has accepted the REMUNE HIV/AIDS vaccine BLA (biologics licensing application) for review for therapeutic treatment in adults with HIV/AIDS. [Immune Response BioPharma, Inc. (PRLog)] Press Release

Sanofi Pasteur Announces FDA Approval of Quadracel DTaP-IPV Vaccine for Children Four through Six Years of Age
Sanofi Pasteur announced that the U.S. Food and Drug Administration (FDA) has approved use of Quadracel™ vaccine for active immunization against diphtheria, tetanus, pertussis and poliomyelitis in children four through six years of age. [Sanofi Pasteur SA] Press Release
Our Plan to Combat and Prevent Antibiotic-Resistant Bacteria
Combating and preventing antibiotic resistance will be a long-term effort. That’s why the Administration is releasing the National Action Plan for Combating Antibiotic Resistant Bacteria. [The White House Blog] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 30th International Papillomavirus Conference & Clinical and Public Health Workshops
September 17-21, 2015
Lisbon, Portugal

Visit our events page to see a complete list of events in the immunology of infectious disease community.
NEW Postdoctoral Position – Host-Pathogen Interactions (University of Pittsburgh)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Position – Immunology (Centre Hospitalier Universitaire Vaudois)

Postdoctoral Fellowship – Human Immunology (University of Pennsylvania)

Postdoctoral Fellow – Innate Immunity (University of Connecticut Health Center)

Research Associate – Cell Biology (University College London)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Postdoctoral Fellow – Infection and Immunity (Wuhan Institute of Virology)

Postdoctoral Fellow – Cytokine Signaling (Inserm)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Immunology of Infectious Disease News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Immunology of Infectious Disease News: Archives | Events | Contact Us