Volume 3.02 | Jan 21

Immunology of Infectious Disease News 3.02 January 21, 2014
Immunology of Infectious Disease News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
New Research Uncovers Key Barrier, Further Advancing the Fight Against HIV
Scientists show that even in nonhuman primates with highly effective immune responses to the simian immunodeficiency virus – so-called “elite controllers” – the disease could still persistently replicate in B cell follicles, which exclude the antiviral killer cells. [Press release from Oregon Health & Science University discussing online prepublication in Nature Medicine] Press Release | Abstract
Free Nature Reviews Immunology Poster: The Immune Response to HIV
 
PUBLICATIONS (Ranked by impact factor of the journal)
Vaccine-Elicited CD4 T Cells Induce Immunopathology after Chronic LCMV Infection
Investigators evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality after challenge with a persistent strain of LCMV. [Science] Abstract | Press Release

A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys
Scientists demonstrate that protein homolog 5 (PfRH5)-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. [Cell Host Microbe] Full Article | Graphical Abstract

Pathogen-Expanded CD11b+ Invariant NKT Cells Feedback Inhibit T Cell Proliferation via Membrane-Bound TGF-β1
Investigators identified CD11b+ invariant natural killer T (NKT) cells as a new subset of regulatory NKT cells in mouse models with infection. [J Autoimmun] Abstract

Deficiency of Antigen-Specific B Cells Results in Decreased Trypanosoma cruzi Systemic but Not Mucosal Immunity Due to CD8 T Cell Exhaustion
Despite their initial hypothesis that mucosal Abs would be important, scientists show that B cells are critical for systemic, but not mucosal, T. cruzi protective immunity. [J Immunol] Abstract

HIV

A Long-Acting Integrase Inhibitor Protects Female Macaques from Repeated High-Dose Intravaginal SHIV Challenge
Researchers examined the pharmacokinetics and efficacy of long-acting GSK1265744 as preexposure prophylaxis against repeat high-dose intravaginal SHIV (simian-human immunodeficiency virus) challenge in female rhesus macaques treated with Depo-Provera (depot medroxyprogesterone acetate), which promotes viral transmission vaginally. [Sci Transl Med] Abstract | Press Release

Expanded Cytotoxic T-Cell Lymphocytes Target the Latent HIV Reservoir
Enhanced HIV-specific immunity may be required for HIV eradication. Administration of autologous, ex vivo expanded, virus-specific, cytotoxic T-lymphocytes derived from HIV infected patients on suppressive antiretroviral therapy were studied. [J Infect Dis] Abstract

HIV-2 Infects Resting CD4+ T Cells but Not Monocyte-Derived Dendritic Cells
Scientists investigated human immunodeficiency virus-type 2 (HIV-2) replication in primary CD4+ T lymphocytes, both activated and non-activated, as well as in monocyte-derived dendritic cells. [Retrovirology] Abstract | Full Article

Long-Term SIV Control in Cynomolgus Macaques Not Associated with Efficient SIV-Specific CD8 T-Cell Responses
The contribution of the CD8 T-cell response to maintaining long-term viral control remains unclear. To address this question, researchers transiently depleted CD8 T cells from five simian immunodeficiency virus (SIV)-infected cynomolgus macaques with long-term viral control and weak CD8 T-cell responses. [J Virol] Abstract

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REVIEWS
The Quest for Correlates of Protection against Tuberculosis
The authors focus on alternative pathways that mediate Mycobacterium tuberculosis (Mtb) control and their potential for serving as markers of protection. The review also discusses the significance of investigating the natural human immune response to Mtb to identify the correlates of protection in vaccination. [Clin Vaccine Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.
 
INDUSTRY NEWS
Health Canada Clears Immunovaccine to Conduct Phase I Clinical Trial of Respiratory Syncytial Virus (RSV) Vaccine
Immunovaccine Inc. announced that it has received clearance from Health Canada to conduct a Phase I clinical study of its RSV vaccine in healthy adults. [Immunovaccine Inc.] Press Release

Johnson & Johnson Announces Formation of Ebola Vaccine Development Consortia, Gains Funding from Innovative Medicines Initiative
Johnson & Johnson announced the formation of consortia with leading global research institutions and non-government organizations to work in conjunction with Janssen Pharmaceutical Companies to accelerate the development of its Ebola vaccine regimen. [Johnson & Johnson Services, Inc.] Press Release

Tekmira Pharmaceuticals and OnCore Biopharma Announce Merger Agreement to Create Leading Global Hepatitis B Virus Company
Tekmira Pharmaceuticals Corporation and OnCore Biopharma, Inc. announced that they have agreed to merge to create a new leading global hepatitis B virus company focused on developing a curative regimen for hepatitis B patients by combining multiple therapeutic approaches. [Tekmira Pharmaceuticals Corporation] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting
February 20-24 2015
Houston, United States

NEW Cellular Therapy 2015 – 8th International Symposium on the Clinical Use of Cellular Products
March 19-20, 2015
Erlangen, Germany

Visit our events page to see a complete list of events in the immunology of infectious disease community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Immunology Animal Models (The Technical University of Denmark)

NEW PhD Position – Infection Biology and Innate Immunity (Helmholtz Centre for Infection Research)

NEW PhD Studentship – Defining Innate Phenotypes Associated with Enhanced Immunity to Johne’s Disease (Teagasc)

NEW Postdoctoral Position – Innate Immune Signaling in Pathogen Infection (Sanford-Burnham Medical Research Institute)

Postdoctoral Fellow – Mechanisms of HIV-1 Immune Control and Dendritic Cell Immunopathology in HIV-1 Infection (Massachusetts General Hospital)

PhD Position – Immunology (University Medical Centre Hamburg-Eppendorf)

Postdoctoral Position – Microbe-Immune Cell Homeostasis (Cleveland Clinic Lerner Research Institute)

Postdoctoral Position – Vaccines for Animal Parasites (Ghent University)

Postdoctoral Position – Group B Streptococcus Interaction in Neonatal Sepsis (Institut Pasteur)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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