|PUBLICATIONS (Ranked by impact factor of the journal)|
Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation
Scientists used Murid Herpesvirus-4 to determine for a latently expressed viral epitope how MHC class-I binding and cytotoxic T cells functional avidity impact host colonization. [PLoS Pathog]
Prophylaxis with a Respiratory Syncytial Virus (RSV) Anti-G Protein Monoclonal Antibody Shifts the Adaptive Immune Response to RSV rA2-Line19F Infection from Th2 to Th1 in BALB/c Mice
Scientists investigated the effect of prophylactic treatment with the intact and F(ab’)2 forms of an anti-G protein monoclonal antibody, 131-2G, on the humoral and cellular adaptive immune response to RSV rA2-line19F challenge in BALB/c mice. [J Virol]
Chlamydia muridarum Infection Associated Host MicroRNAs in the Murine Genital Tract and Contribution to Generation of Host Immune Response
Researchers analyzed miRs in the genital tract following C. muridarum (murine strain of Chlamydia trachomatis) challenge of wild type and CD4+ T-cell deficient C57BL/6 mice at days 6 and 12 post-challenge. [Am J Reprod Immunol]
Increased T-Cell Responses to EBV with High Viral Load in Patients with EBV-Positive Diffuse Large B-Cell Lymphoma
Immunological status of patients with EBV-positive diffuse large B-cell lymphoma (EBV+DLBCL) without obvious immunodeficiency has not been elucidated. A multi-center prospective study was conducted to assess pretreatment T-cell responses to EBV, EBV-DNA load, and anti-EBV antibody in these patients. [Leuk Lymphoma]
A Macrophage-Stimulating Compound from a Screen of Microbial Natural Products
Streptazolin increased bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Researchers showed that streptazolin stimulates the macrophage nuclear factor κB pathway via phosphatidylinositide 3-kinase signaling, and that the conjugated diene moiety is essential for stimulatory activity. [J Antibiot]
Early Initiation of Combined Antiretroviral Therapy Preserves Immune Function in the Gut of HIV-Infected Patients
To better understand determinants of gut mucosal restoration, scientists performed phenotypic and gene expression analyses of the gut from HIV-infected patients, naive or treated with combined antiretroviral therapy initiated either at the early phase of the primary infection or later during the chronic phase. [Mucosal Immunol]
A CD4+ T Cell Antagonist Epitope Down-Regulates Activating Signaling Proteins, Up-Regulates Inhibitory Signaling Proteins and Abrogates HIV-Specific T Cell Function
In HIV infection it has been shown that peptide sequence variation can reduce CD4+ T cell responses to the virus, and small changes to peptide sequences can transform agonist peptides into antagonist peptides. The authors describe, at a molecular level, the consequences of antagonism of HIV p24-specific CD4+ T cells. [Retrovirology]
Homeostatic Cytokines Induce CD4 Downregulation in African Green Monkeys Independent of Antigen Exposure to Generate SIV-resistant CD8αα T Cells
Scientists showed that juvenile African green monkeys (AGMs) accelerate CD4 to CD8αα conversion upon SIV infection and avoid progression to AIDS. The CD4 downregulation induced by SIV infection is not limited to SIV-specific T cells, and vaccination of an adult AGM who had a negligible number of CD4 T cells demonstrated that CD4 downregulation can occur without antigenic exposure. [J Virol]
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