New Monkey Model for AIDS Offers Promise for Medical Research
Scientists announced that they have coaxed a slightly modified form of the HIV-1 virus to not only infect pigtailed macaques, a species of monkey, but to cause full blown AIDS in the primates, a first. If fully developed, the macaque model will offer a substantial improvement for research. [Press release from The Rockefeller University discussing online prepublication in Science]
Press Release|Abstract
Host-Directed Therapy of Tuberculosis Based on Interleukin-1 and Type I Interferon Crosstalk
Researchers demonstrate that interleukin-1 (IL-1) confers host resistance through the induction of eicosanoids that limit excessive type I interferon (IFN) production and foster bacterial containment. They showed that, in infected mice and patients, reduced IL-1 responses and/or excessive type I IFN induction are linked to an eicosanoid imbalance associated with disease exacerbation. [Nature]
Abstract
HIV Infection and Incidence of Ischemic Stroke
Scientists aimed to determine the association of HIV infection and immunodeficiency with incidence of ischemic stroke. Ischemic stroke incidence in HIV-positive individuals with high CD4 or low HIV RNA is similar to that of HIV-negative individuals. [AIDS]
Abstract|Press Release
Improved Flow-Based Method for HIV/SIV Envelope-Specific Memory B-Cell Evaluation in Rhesus Macaques
Scientists developed an improved flow cytometry-based method for the rapid and efficient identification of gp120-specific memory B cells in peripheral blood, bone marrow, and mucosal tissues which allows their direct staining without the need for prior cell sorting or enrichment. They demonstrate staining of both HIV and SIV envelope-specific memory B cells in PBMC, bone marrow, and rectal tissue of vaccinated and infected rhesus macaques. [J Immunol Methods]
Abstract
Ectopic Lymphoid-Like Structures in Infection, Cancer and Autoimmunity
The authors discuss investigations in both experimental model systems and patient cohorts to provide a perspective on the formation and functions of ectopic lymphoid-like structures in human pathology, with particular reference to the clinical implications and the potential for therapeutic targeting. [Nat Rev Immunol]
Abstract
Visit our reviews page to see a complete list of reviews in the infectious disease research field.
INDUSTRY NEWS
ATCC Teams with CDC and Thermo Fisher Scientific on Public Health RT-PCR Assay
American Type Culture Collection (ATCC) has licensed technology from the Centers for Disease Control and Prevention (CDC) and partnered with Thermo Fisher Scientific, to bring a rapid and cost-effective PCR-based method of monitoring HIV drug resistance to resource-limited countries. [ATCC]
Press Release
Recruit Top Talent: Reach more than 50,000 potential candidates by posting
your organization’s career opportunities on the Connexon Creative Job Board at no cost.
Have we missed an important article or publication in Immunology of Infectious Disease News? Click here to submit!
Comments or Suggestions? Submit your feedback here.
