Volume 2.24 | Jun 25

Immunology of Infectious Disease News 2.24 Jun 25, 2014
Immunology of Infectious Disease News
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TOP STORY
New Monkey Model for AIDS Offers Promise for Medical Research
Scientists announced that they have coaxed a slightly modified form of the HIV-1 virus to not only infect pigtailed macaques, a species of monkey, but to cause full blown AIDS in the primates, a first. If fully developed, the macaque model will offer a substantial improvement for research. [Press release from The Rockefeller University discussing online prepublication in Science] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Host-Directed Therapy of Tuberculosis Based on Interleukin-1 and Type I Interferon Crosstalk
Researchers demonstrate that interleukin-1 (IL-1) confers host resistance through the induction of eicosanoids that limit excessive type I interferon (IFN) production and foster bacterial containment. They showed that, in infected mice and patients, reduced IL-1 responses and/or excessive type I IFN induction are linked to an eicosanoid imbalance associated with disease exacerbation. [Nature] Abstract

Immunization with a Functional Protein Complex Required for Erythrocyte Invasion Protects against Lethal Malaria
Scientists provide evidence that immunization with an apical membrane antigen 1 (AMA1)-RON2 peptide complex, but not with AMA1 alone, provided complete protection against a lethal Plasmodium yoelii challenge in mice. Significantly, IgG from mice immunized with the complex transferred protection. [Proc Natl Acad Sci USA] Abstract | Full Article | Press Release

Artesunate versus Chloroquine Infection-Treatment-Vaccination Defines Stage-Specific Immune Responses Associated with Prolonged Sterile Protection against Both Pre-Erythrocytic and Erythrocytic Plasmodium yoelii Infection
Researchers used the different effects of antimalarial drugs chloroquine and artesunate on blood stage parasites to dissect the stage-specific immune responses in mice immunized with P. yoelii sporozoites (spz) under either drug, as well as their ability to protect mice against challenge with spz or infected RBCs. [J Immunol]
Abstract | Full Article

The Transcription Factor Nuclear Factor of Activated T Cells c3 Modulates the Function of Macrophages in Sepsis
Investigators showed that transcription factor nuclear factor of activated T cells (NFAT) c3 regulates expression of inducible nitric oxide synthase in macrophages stimulated with lipopolysaccharide. NFATc3 KO mice subjected to sepsis show that NFATc3 is necessary for bacterial clearance in mouse lungs during sepsis. [J Innate Immun] Abstract | Press Release

Protective Role of TNF-α, IL-10 and IL-2 in Mice Infected with the Oshima Strain of Tick-Borne Encephalitis Virus
Researchers investigated the roles of the TNF-α, IL-10 and other cytokines in appropriate KO mice following infection with Oshima and Sofjin strains of tick-borne encephalitis virus. [Sci Rep] Full Article

HIV

Glycosphingolipid-Functionalized Nanoparticles Recapitulate CD169-Dependent HIV-1 Uptake and Trafficking in Dendritic Cells
Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells. [Nat Commun] Abstract

HIV Infection and Incidence of Ischemic Stroke
Scientists aimed to determine the association of HIV infection and immunodeficiency with incidence of ischemic stroke. Ischemic stroke incidence in HIV-positive individuals with high CD4 or low HIV RNA is similar to that of HIV-negative individuals. [AIDS] Abstract | Press Release

Incomplete Recovery of Pneumococcal CD4 T Cell Immunity after Initiation of Antiretroviral Therapy in HIV-Infected Malawian Adults
HIV-infected adults were followed up at 3, 6 and 12 months after initiating antiretroviral therapy (ART). Pneumococcal-specific CD4 T-cell immunity was assessed by IFN-γ ELISpot, proliferation assay, CD154 expression and intracellular cytokine assay. [PLoS One] Full Article

Improved Flow-Based Method for HIV/SIV Envelope-Specific Memory B-Cell Evaluation in Rhesus Macaques
Scientists developed an improved flow cytometry-based method for the rapid and efficient identification of gp120-specific memory B cells in peripheral blood, bone marrow, and mucosal tissues which allows their direct staining without the need for prior cell sorting or enrichment. They demonstrate staining of both HIV and SIV envelope-specific memory B cells in PBMC, bone marrow, and rectal tissue of vaccinated and infected rhesus macaques. [J Immunol Methods] Abstract

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REVIEWS
Ectopic Lymphoid-Like Structures in Infection, Cancer and Autoimmunity
The authors discuss investigations in both experimental model systems and patient cohorts to provide a perspective on the formation and functions of ectopic lymphoid-like structures in human pathology, with particular reference to the clinical implications and the potential for therapeutic targeting. [Nat Rev Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the infectious disease research field.

Microbiology and Infectious Disease Congress 2014
 
INDUSTRY NEWS
ATCC Teams with CDC and Thermo Fisher Scientific on Public Health RT-PCR Assay
American Type Culture Collection (ATCC) has licensed technology from the Centers for Disease Control and Prevention (CDC) and partnered with Thermo Fisher Scientific, to bring a rapid and cost-effective PCR-based method of monitoring HIV drug resistance to resource-limited countries. [ATCC] Press Release

Cepheid and Leading Pharmaceutical Companies Partner on a Diagnostic Test to Help Tackle Multidrug-Resistant Bacterial Infections
Cepheid announced a new collaboration with AstraZeneca, Cubist Pharmaceuticals, Inc., and GSK intended to promote transformational change in infectious disease therapy by developing a rapid diagnostic test that can target multi-drug resistant pathogens and support the appropriate use of antibiotics. [Cepheid] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Frontiers of Immunology in Health and Diseases
September 2-6, 2014
Suzhou, China

Visit our events page to see a complete list of events in the infectious disease community.
 
JOB OPPORTUNITIES
NEW Principal Investigator Positions – Systems & Synthetic Biology (Institute for Research in Immunology and Cancer)

NEW Postdoctoral Associate – Enveloped Viruses (Scripps Research Institute)

Postdoctoral Scientist – Immune Focused In Vitro Analytics (Celentyx Ltd.)

Postdoctoral Fellow – Retroviral Evolution (Leidos Biomedical Research, Inc.)

Postdoctoral Associate – Innate Immunology/Pattern Recognition Receptor Responses and Virus-Host Interactions (Sanford Burnham Medical Research Institute)

Postdoctoral Fellow – Plasmodium/Anopheles Interactions (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado)

Postdoctoral Associate – Bacterial Pathogenesis, Bioengineering and Cellular Biomechanics (Arizona State University, Biodesign Institute)

PhD Studentship – Microbiology & Immunology (INRS – University of Quebec)

Postdoctoral Fellow – Immunology and Virology (National University of Singapore)

Principal Investigator – Molecular Mechanisms of Inflammation (Inflammation Research Center – VIB-UGent)

Postdoctoral Position – Intestinal Mucosal Immunology and Inflammation (Universität Bern)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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