|PUBLICATIONS (Ranked by impact factor of the journal)|
A New Transcriptional Role for Matrix Metalloproteinase-12 in Antiviral Immunity|
Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) researchers showed that IFN-α is retained in the cytosol of virus-infected cells and is not secreted. They showed here that after macrophage secretion, MMP-12 is transported into virus-infected cells. [Nat Med]
Cationic Antimicrobial Peptides Promote Microbial Mutagenesis and Pathoadaptation in Chronic Infections
Researchers’ findings confirmed the current view that reactive oxygen species can promote mucoidy in vitro, but revealed polymorphonucleocytes are proficient at inducing mucoid conversion in the absence of an oxidative burst. [PLoS Pathog]
Full Article |
Mesenchymal Stem Cells Infected with Mycoplasma arginini Secrete Complement C3 to Regulate Immunoglobulin Production in B Lymphocytes
Scientists showed that the conditioned medium (CM) of mesenchymal stem cells (MSCs) infected with a mycoplasma strain, Mycoplasma arginini, has marked inhibitory effects on immunoglobulin production by lipopolysaccharide/interleukin-4-induced B cells compared with mycoplasma-free MSC-CM. [Cell Death Dis]
Human Immune Responses to H. pylori HLA Class II Epitopes Identified by Immunoinformatic Methods
To characterize the complexity of the CD4+ T cell response generated during H. pylori infection, computational methods were previously used to generate a panel of 90 predicted epitopes conserved among H. pylori genomes that broadly cover HLA Class II diversity for maximum population coverage. These sequences were tested individually for their ability to induce in vitro responses in peripheral blood mononuclear cells by interferon-γ ELISpot assay. [PLoS One]
Full Article |
Reductive Methylation and Mutation of an Anthrax Toxin Fusion Protein Modulates its Stability and Cytotoxicity
Investigators characterized an anti-cancer fusion protein consisting of anthrax lethal factor and the catalytic domain of Pseudomonas exotoxin A by mutating the N-terminal amino acids and by reductive methylation to dimethylate all lysines. The two described modifications offer unique advantages such as increased cytotoxic activity and diminished antibody recognition, and thus may be applicable to other therapeutic proteins that act in the cytosol of cells. [Sci Rep]
Antiviral Activity of Ginseng Extract against Respiratory Syncytial Virus Infection
Researchers investigated whether Panax Korean red ginseng extract (KRGE) has in vitro and in vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE treatment suppressed the expression of RSV-induced inflammatory cytokine genes (IL-6 and IL-8) and the formation of reactive oxygen species in epithelial cell cultures. [Int J Mol Med]
Alterations in Cholesterol Metabolism Restrict HIV-1 Trans Infection in Nonprogressors
Researchers showed that two types of professional antigen-presenting cells, i.e., dendritic cells and B lymphocytes, from HIV-1-infected nonprogressors lacked the ability to mediate HIV-1 trans infection of CD4+ T cells. [mBio]
Full Article |
NK Cells Are Primed by ANRS MVAHIV-Infected Dendritic Cells, via a Mechanism Involving NKG2D and Membrane-Bound IL-15, to Efficiently Control HIV-1 Infection in CD4+ T Cells
Researchers showed that Modified Vaccinia Ankara encoding an HIV polypeptide (MVAHIV)-primed natural killer (NK) cells display a greater capacity to control HIV-1 infection in autologous CD4+ T cells. [Eur J Immunol]
NKT Cell Depletion in Humans during Early HIV Infection
Researchers studied human peripheral blood natural killer T (NKT) cell levels, phenotype and function in 31 human immunodeficiency virus (HIV)-infected subjects not on antiretroviral treatment from a mean of 4 months to 2 years after HIV infection. They found that peripheral CD4+ NKT cells were substantially depleted and dysfunctional by 4 months after HIV infection. [Immunol Cell Biol]
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Innate Immunity to Influenza Virus Infection|
The authors discuss the various ways in which the innate immune system uses pattern recognition receptors to detect and respond to influenza virus infection. They consider whether the outcome of innate sensor stimulation promotes antiviral resistance or disease tolerance, and propose rational treatment strategies for the acute respiratory disease that is caused by influenza virus infection. [Nat Rev Immunol]
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