Volume 2.13 | Apr 9

Immunology of Infectious Disease News 2.13 April 9, 2014
Immunology of Infectious Disease News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Find Genetic Trigger for RSV-Induced Infant Hospitalizations
Researchers have pinpointed a viral protein that plays a major role in making respiratory syncytial virus (RSV) the most common cause of hospitalization in children under one year of age. [Press release from the University of North Carolina at Chapel Hill School of Medicine discussing online prepublication in The Journal of Clinical Investigation] Press Release | Full Article
Learn more about the new smartphone app for human blood cell frequencies
 
PUBLICATIONS (Ranked by impact factor of the journal)
Inhibition of Langerhans Cell Maturation by Human Papillomavirus Type 16: A Novel Role for the Annexin A2 Heterotetramer in Immune Suppression
Results demonstrated that human papillomavirus-16 suppresses Langerhans cells maturation through an interaction with the annexin A2 heterotetramer, revealing a novel role for this protein. [J Immunol] Abstract

Gr-1dimCD11b+ Immature Myeloid-Derived Suppressor Cells but Not Neutrophils Are Markers of Lethal Tuberculosis Infection in Mice
Researchers showed that in mice, tuberculosis progression is associated with the accumulation of cells that express neutrophilic markers Gr-1 and Ly-6G but do not belong to conventional neutrophils. [J Immunol] Abstract

Regulatory Phenotype, PD-1 and TLR3 Expression in T Cells and Monocytes from HCV Patients Undergoing Antiviral Therapy: A Randomized Clinical Trial
The authors aimed to clarify the response of peripheral T cells and monocytes in chronic hepatitis C patients with antiviral treatment. [PLoS One] Full Article

Interferon-Mediated Innate Immune Responses against Malaria Parasite Liver Stages
Using RNA sequencing, investigators showed that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. [Cell Rep]
Abstract | Full Article | Graphical Abstract

HIV

Reduction of HIV Persistence following Transplantation in HIV-Infected Kidney Transplant Recipients
Investigators explored the impact of immunosuppressant therapy on peripheral blood measures of human immunodeficiency virus (HIV) persistence following kidney transplantation. [Am J Transplant]
Abstract | Press Release

Diverse Viral Glycoproteins as Well as CD4 Co-Package into the Same Human Immunodeficiency Virus (HIV-1) Particles
To determine if co-packaging occurs among different glycoproteins, researchers designed an assay that combines virion antibody capture and a determination of infectivity based on a luciferase reporter. [Retrovirology] Full Article

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through TNF-α and TLR4 Mediated Mechanisms
The authors aimed to determine whether and how HIV-1 Tat protein, an immunosuppressive viral factor, induces the PD-1/PD-L1 co-inhibitory pathway on human dendritic cells. [J Virol] Abstract

HIV-1 Nef Impairs Key Functional Activities in Human Macrophages through CD36 Downregulation
Investigators showed that HIV-1 Nef protein may have a role in the strategies elaborated by HIV-1 to alter pathogen disease outcomes, by modulating CD36 expression in macrophages, favoring the onset of opportunistic infections in HIV-1 infected people. [PLoS One] Full Article

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Free Poster: Quick Reference for Mouse Immune Cell Frequencies and Percentages
 
REVIEWS
Investigating the Role of NOD-Like Receptors in Bacterial Lung Infection
This article addresses current understanding of the structure and function of NOD-like receptor family members, highlighting recent advances and gaps in knowledge with the specific focus on immune responses in the respiratory tract during bacterial infection. [Am J Respir Crit Care Med] Abstract

Mesenchymal Stromal Cells in the Antimicrobial Host Response of Hematopoietic Stem Cell Recipients with Graft-versus-Host Disease – Friends or Foes?
The authors focus on the available data from in vitro studies and animal models regarding the interaction of mesenchymal stromal cells with bacterial, viral, and fungal pathogens. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the infectious disease research field.
 
INDUSTRY NEWS
WHO Issues Its First Hepatitis C Treatment Guidelines
WHO has issued its first guidance for the treatment of hepatitis C. The publication of the “WHO Guidelines for the screening, care and treatment of persons with hepatitis C infection” coincides with the availability of more effective and safer oral hepatitis medicines, along with the promise of even more new medicines in the next few years. [World Health Organization] Press Release | Guidelines

XBiotech Announces In-Licensing of Technology from Strox Biopharmaceuticals
XBiotech announced that it acquired the patent estate of Strox Biopharmaceuticals relating to antibody therapies for methicillin resistant Staphylococcus aureus. [XBiotech USA, Inc.] Press Release

Pediatrician and Pediatric Infectious Disease Specialist Joins Loyola University Health System
Nadia K. Qureshi, MD, has brought her expertise in pediatric infectious disease and general pediatrics to Loyola University Health System. She also is an assistant professor in the Department of Pediatrics at Loyola University Chicago Stritch School of Medicine. [Loyola University Health System] Press Release

From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 28th European Immunogenetics and Histocompatibility Conference: From Genes to Therapy
June 25-28, 2014
Stockholm, Sweden

NEW Federation of Clinical Immunology Societies (FOCiS) 2014: Spotlight on Translational Immunology
June 25-28, 2014
Chicago, United States

Visit our events page to see a complete list of events in the infectious disease community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Infectious Disease and Novel Autoimmune Disease Models (The Wistar Institute)

Professorship Position – Infectious Diseases and Tropical Medicine (Medical University of Vienna)

Postdoctoral Positions – Virus-Host Interactions and Liver Disease (University of Strasbourg)

Postdoctoral Position – Intestinal Mucosal Immunology and Inflammation (Universität Bern)

PhD Position – Virology (Hannover Medical School)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Fellow – AIDS Research (Leidos Biomedical Research, Inc.)

Postdoctoral Fellow – Immunology of Infection (CNRS – Institute of Pharmacology and Structural Biology)

Faculty Position – Vaccine Immunology (Cornell University)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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