|PUBLICATIONS (Ranked by impact factor of the journal)|
| Salmonella typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP|
S. typhimurium suppressed degranulation of local mast cells (MCs), resulting in limited neutrophil recruitment and restricting outflow of vascular contents into infection sites, thus facilitating bacterial spread. MC suppression was mediated by secreted effector protein (SptP), which shares structural homology with Yersinia YopH. [Immunity] Abstract | Press Release
Molecular Signatures of Antibody Responses Derived from a Systems Biology Study of Five Human Vaccines
Investigators did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. [Nat Immunol] Abstract | Press Release
Salmonella Exploits NLRP12-Dependent Innate Immune Signaling to Suppress Host Defenses during Infection
Investigators showed that nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 12 (NLRP12)-deficient mice were highly resistant to S. typhimurium infection. Salmonella-infected macrophages induced NLRP12-dependent inhibition of NF-κB and ERK activation by suppressing phosphorylation of IκBα and ERK. [Proc Natl Acad Sci USA] Abstract
The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages
Investigators hypothesized that the ability of evolved bacteria to escape specific components of host innate immunity, such as phagocytosis and killing by macrophages, is a critical trait relevant in the acquisition of bacterial virulence. [PLoS Pathog] Full Article
Immunological and Virological Mechanisms of Vaccine-Mediated Protection against SIV and HIV
The authors showed that antibodies to the simian immunodeficiency virus (SIV) envelope are necessary and sufficient to prevent infection. Moreover, sequencing of viruses from breakthrough infections revealed selective pressure against neutralization-sensitive viruses; they identified a two-amino-acid signature that alters antigenicity and confers neutralization resistance. [Nature] Abstract | Press Release
Myeloid Dendritic Cells Induce HIV-1 Latency in Non-Proliferating CD4+ T Cells
Scientists demonstrated that co-culture of resting CD4+ T cells and syngeneic myeloid dendritic cells can dramatically increase the frequency of HIV DNA integration and latent HIV infection in non-proliferating memory, but not naïve, CD4+ T cells. [PLoS Pathog] Full Article
The Impact of Unprotected T Cells in RNAi-Based Gene Therapy for HIV-AIDS
For the development of a durable gene therapy that prevents viral escape, researchers proposed to combine multiple shRNAs against highly conserved regions of the HIV-1 RNA genome. [Mol Ther] Abstract
Increased Glucose Metabolic Activity Is Associated with CD4+ T-Cell Activation and Depletion during Chronic HIV Infection
Scientists investigated the impact of HIV infection on key processes that regulate glucose uptake and metabolism in primary CD4+ and CD8+ T cells. [AIDS] Abstract
CD8+ T Cells from HLA-B*57 Elite Suppressors Effectively Suppress Replication of HIV-1 Escape Mutants
Researchers investigated the effect of escape mutations within HLA*B-57-restricted Gag epitopes on the CD8+ T cell mediated suppression of HIV-1 replication. [Retrovirology] Abstract | Full Article
|Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News!|
| NOD Proteins: Regulators of Inflammation in Health and Disease|
Recent findings have expanded the scope of the cellular compartments monitored by nucleotide-binding oligomerization domain 1 (NOD1) and NOD2 and have elucidated the signaling pathways that are triggered downstream of NOD activation. In vivo, NOD1 and NOD2 have complex roles, both during bacterial infection and at homeostasis. [Nat Rev Immunol] Abstract
Visit our reviews page to see a complete list of reviews in the infectious disease research field.
Have we missed an important article or publication in Immunology of Infectious Disease News?
Click here to submit!
Comments or Suggestions? Submit your feedback here.